While Boldenone is officially classified as a veterinarian grade, the first batches of Boldenone were introduced on the human grade pharmaceutical market by Ciba in the early 1950’s under the brand name Parenabol. Human grade Boldenone would see some success in human medicine through the 1960’s and 1970’s but would ultimately be discontinued by the end of the decade. Since that time, Boldenone has only been available through veterinarian medicine and underground labs with the Equipoise name dominating the market.

Boldenone is a structurally altered form of testosterone. It is a very slight change in an added double bond at the carbon one and two position. This double bond greatly reduces the hormone’s androgenicity, as well as estrogenic nature. Due to its structural change, Equipoise only aromatizes at approximately 50% the rate of testosterone. Estrogenic side effects are possible, but the odds are highly in the individual’s favor compared to testosterone. It is not as powerful for a mass of a builder as testosterone, not even close, but the reduced estrogenic activity should allow the individual to make cleaner gains through supplementation.

Boldenone shares many similarities regarding direct enhancement properties with testosterone. Common shared properties include its ability to enhance protein synthesis, nitrogen retention in the muscles, inhibit glucocorticoid hormones and increase igf-1 output. Boldenone is also well known for increasing red blood cell count. However, issues of concern have been noted regarding how much Boldenone can increase red blood cell count. But available data tends to support this only being a concern with extremely high dose use for extremely long periods of time. In many ways, the increase in red blood cells provided by Equipoise can be fast and rapid, but may not present a significant advantage or disadvantage compared to most anabolic steroids when used responsibly. Without question, a moderate increase in cell production would be very advantageous for almost any athlete.

Boldenone is a generally a well-tolerated anabolic steroid for most men, and is often very well-tolerated by many women when low doses are applied. Side effects of Equipoise use are certainly possible, but most healthy adults should find this anabolic steroid very manageable.

Boldenone hormone does not aromatize heavily, but it is aromatized to estrogen. This is due to the testosterone hormone’s interaction with the aromatize enzyme. High levels of estrogen can prove problematic in their promotion of gynecomastia, excess water retention and high blood pressure if water retention becomes severe. Due to the moderate level of aromatizing activity, most men should find related side effects very easy to control. Moderate doses should be manageable, but many will find high doses to require added attention.

In order to combat the estrogenic side effects of Equipoise, an anti-estrogen medication is sometimes needed. Not all will need an anti-estrogen when using this steroid, but it’s always a good idea to at least have one on hand. The anti-estrogen medications you can choose include Selective Estrogen Receptor Modulators (SERM’s) like Nolvadex, and Aromatase Inhibitors (AI’s) like Arimidex.