Armodafinil is the R-enantiomer of the racemic synthetic agent modafinil with central nervous system (CNS) stimulant and wakefulness-promoting activities. Although the exact mechanism of action has yet to be fully elucidated, armodafinil appears to inhibit the reuptake of dopamine by binding to the dopamine-reuptake pump, which leads to an increase in extracellular dopamine levels in some brain regions. Armodafinil has a longer half-life than modafinil

Modafinil and its R-enantiomer armodafinil are central nervous system stimulants used to improve wakefulness in patients with excessive sleepiness.


Peak plasma concentrations are attained at approximately 2 hours when fasted, and can be delayed approximately 2-4 hours in a fed state. Since the delay in tmax is also associated with elevated plasma concentrations later in time, food can potentially affect the onset and time course of pharmacologic action for armodafinil.

Nuvigil (armodafinil) is a single-isomer of modafini. The exact mechanism of action is unknown. Armodafinil belongs to a class of drugs known as eugeroics, which are stimulants that provide long-lasting mental arousal. Armodafinil benefits are similar in a lot of respects to those associated with Modafinil. The wakefulness effect is very noticeable, similar to a powerful dose of caffeine. The exception is that unlike caffeine there are no jitters or nervousness and it does not increase (nor decrease) blood pressure or pulse rate.

Armodafinil is also recognized to be quite safe and has almost zero addictive potential (Modafinil does have a slightly higher potential for side effects and tolerance).

  • Treshold: 20-40mg
  • Light: 40-100mg
  • Common: 100-200mg
  • Strong: 200-300mg
  • Heavy: 300mg+
After effects‎: ‎2 - 12 hours
  • Onset‎: ‎20 - 60 minutes
  • Peak‎: ‎4 - 7 hours
  • Come up‎: ‎1 - 2.5 hour

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